![]() ![]() Pre-treatment of rats with 50 mg kg(-1) rutaecarpine caused a 3-fold increase in theophylline clearance and a 70%, 68% and 68% decrease in the area under the concentration-time curve (AUC), mean residence time (MRT) and half-life, respectively. Rutaecarpine pre-treatment increased the clearance of theophylline in a dose-dependent manner. Pharmacokinetic parameters of theophylline were determined using a microdialysis sampling method. In the lungs, EROD activity was elevated from an undetectable to a detectable level by rutaecarpine. In the kidney, rutaecarpine treatment caused a 3-fold increase in EROD activity. Oral treatment of Sprague-Dawley rats with 50 mg kg(-1) rutaecarpine for three days through a gastrogavage caused a 4- and 3-fold increase in liver microsomal 7-ethoxyresorufin O-deethylation (EROD) and 7-methoxyresorufin O-demethylation activity, respectively. To evaluate the pharmacokinetic interaction of theophylline with rutaecarpine, the effects of rutaecarpine on CYP1A2 activity and theophylline pharmacokinetics were investigated. The cytochrome P450 (CYP) 1A2 substrate, theophylline, is an important therapeutic agent for the treatment of asthma, but has a narrow therapeutic index. Hamet R (1962) Pressure and respiratory effects of evodiamine of Yasuhiko Asahima.Rutaecarpine is a main active alkaloid present in the medicinal herb, Evodia rutaecarpa. Yang HY, Li SY, Chen CF (1988) Hypotensive effects of dehydroevodiamine, a quinazólinocar-boline alkaloid isolated from Evodia rutaecarpa. Xu SB, Huang YM, Lau CNB, Wat CKH, Kong YC (1982) Hypotensive effect of dehydroevo-diamine from Evodiae fructus. Kong YC (1982) Evodia rutaecarpa, from Pents’ao to action mechanism. King CL, Kong YC, Wong NS, Yeung HW, Fong HHS, Sankawa U (1980) Uterotonic effect of Evodia rutaecarpa alkaloids. Li MT, Huang HI (1966) Studies on the chemical constituents of the Chinese drug Shih-Hu ( Evodia rutaecarpa var. Takahashi M, Cyong JC, Hanabusa K (1980) Cyclic GMP in Evodiae fructus. Chem Pharm Bull (Tokyo) 30:2463–2466Ĭyong JC, Takahashi M, Hanabusa K, Otsuka Y (1982) Guanosine 3′,5′-monophosphate in fruits of Evodia rutaecarpa and E. Phyto-chemistry 14:838–839Ĭyong JC, Takahashi M (1982) Purification and identification of guanosine 3′,5′-monophos-phate from higher plants (Evodiae fructus). Grimshaw J, Lamer-Zarawaka E (1975) Isopentenylflavanone from Evodia rutaecarpa. Hirose Y, Kondo K, Arita H, Fujita A (1967) Components of Evodia fruit. Sugimoto T, Ueno A, Kadota S, Cut CB, Kikuchi T (1988) New 5 β-H limonoids from Evodia rutaecarpa Bentham. J Chem Soc 255–275ĭreyer DL (1967) Citrus bitter principles VII. The constitutions of limonin and related bitter principles. J Chem Soc 4183–4200īarton DHR, Pradhan SK, Sternhell S, Templeton JF (1961) Triterpenoids. J Pharm Soc Jpn 69:322–325Īrnott S, Davie AW, Robertson JM, Sim GA, Watson DG (1961) The structure of limonin: X-ray analysis of epilimonin iodoacetate. Maeda S (1935) Constituents of Evodia danielli Hemsl. Shoji N, Umeyama A, Iuchi A, Saito N, Takemoto T, Nomoto K, Ohizumi Y (1988) Isolation of a new alkaloid from Evodia rutaecarpa. Sugimoto T, Miyase T, Kuroyanagi M, Ueno A (1988) Limonoids and quinolone alkaloids from Evodia rutaecarpa Bentham. Takagi S, Akiyama T, Konoshita T, Sankawa U, Shibata S (1979) Minor basic constituents of Evodia fruits. Takagi S, Kinoshita T, Sameshima M, Akiyama T, Kobayashi S, Sankawa U (1979) Isolation of synephrine from Evodia fruits. Kamikado T, Chang CF, Murakoshi S, Sakurai A, Tamura S (1976) Isolation and structure elucidation of three quinolone alkaloids from Evodia rutaecarpa. Yamazaki M, Kawana T (1967) Isolation of hydroxyevodiamine (rhetisinine) from the fruits of Evodia rutaecarpa. Tschesche R, Werner W (1967) Evocarpin, ein neues Alkaloid aus Evodia rutaecarpa. Nakasato T, Asada S, Marui K (1962) Dehydroevodiamine, main alkaloid from the leaves of Evodia rutaecarpa. Agrie Biol Chem 42:1515–1519ĭanieli B, Lesma G, Palmisano G (1979) A new tryptophan derived alkaloid from Evodia rutaecarpa (Juss.) Benth. Kamikado T, Murakoshi S, Tamura S (1978) Structure elucidation and synthesis of alkaloids isolated from fruits of Evodia rutaecarpa. Akademie, Berlin, p 741Ĭhu JH (1951) Constituents of the Chinese drug Wu-Chu-Yu, Evodia rutaecarpa. Chem Ber 61:319–321īoit HG (1960) Ergebnisse der Alkaloid-Chemie bis 1960. Asahina Y, Ohta T (1928) Eine Synthese des Evodiamins. ![]()
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |